Studies in neuroscience demonstrate that a focus on mindfulness meditation and contemplative spiritual practice has the capacity to increase our non-anxious awareness and significantly lower our stress. Not only is this finding of immediate importance for pastoral counselors and psychotherapists, it will even necessitate a paradigm shift in the way that pastoral and spiritual practitioners approach the general care of souls. The starting point for such a paradigm shift is an acknowledgement of the built-in negativity bias of the brain, and how certain beliefs and theological views may inadvertently reinforce the bias to the detriment of individuals and faith communities. Once necessary for human survival, the ingrained bias can often be excessive for today’s world, resulting in negatively disproportionate assessments of life events and human relationships. To balance the neural predisposition toward negativity and anxious awareness, it is necessary for clinical and spiritual practitioners, and those in their care, to develop a regular spiritual practice consisting of, for example, contemplative prayer or mindfulness meditation.